{"product_id":"highly-absorbed-thiamine","title":"Highly Absorbed Thiamine","description":"\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e120 Capsules (60-day Supply)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"pi-list-with-icons pi-list-icons-right-open\" data-mce-fragment=\"1\"\u003e\n\u003cli data-mce-fragment=\"1\"\u003eSupports Healthy Thiamin Status*\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eSupports Vascular Health*\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eSupports Nerve Health*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-mce-fragment=\"1\"\u003e \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003cem data-mce-fragment=\"1\"\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.\u003c\/em\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHighly Absorbed Thiamine: Overview\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eDoctor Emi's\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003eHighly Absorbed Thiamine\u003c\/span\u003e\u003c\/strong\u003e \u003cspan data-mce-fragment=\"1\"\u003eis a lipid-soluble derivative of thiamin that demonstrates improved absorption and duration of activity compared to water-soluble thiamin. \u003cstrong data-mce-fragment=\"1\"\u003eHighly Absorbed Thiamine\u003c\/strong\u003e activates transketolase activity, thereby facilitating conversion of harmful glucose metabolites and positively affecting AGE formation. It supports peripheral nerve health and may support vascular health, including the microvasculature of the retina and kidney. \u003cstrong data-mce-fragment=\"1\"\u003eHighly Absorbed Thiamine\u003c\/strong\u003e is also an excellent way to improve thiamin status.*\u003c\/span\u003e\u003c\/p\u003e\n\u003cul data-mce-fragment=\"1\"\u003e\n\u003cli data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eNon-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eSoy-Free\u003c\/span\u003e\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eGluten-Free\u003c\/span\u003e\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eMade in the USA\u003c\/span\u003e\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eManufactured in a \u003ca href=\"https:\/\/store.doctoremi.com\/pages\/gmp-certification\" data-mce-fragment=\"1\" data-mce-href=\"https:\/\/store.doctoremi.com\/pages\/gmp-certification\" target=\"_blank\"\u003eGMP\u003c\/a\u003e Compliant Facility\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eDOES NOT CONTAIN: wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHighly Absorbed Thiamine: Directions\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eTake two capsules in the morning and two capsules in the evening, or as directed by your healthcare practitioner.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eConsult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHighly Absorbed Thiamine: Other Ingredients\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eMicrocrystalline cellulose, HPMC (capsule), ascorbyl palmitate, silica, and medium-chain triglyceride oil.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHighly Absorbed Thiamine: Storage\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eKeep closed in a cool, dry place out of reach of children.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHighly Absorbed Thiamine: In-Depth Information\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThe excellent pharmacokinetic profile of lipid-soluble\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eHighly Absorbed Thiamine\u003c\/strong\u003e\u003c\/span\u003e (S-benzoylthiamine O-monophosphate) is the reason why many practitioners select it in preference to other forms of supplemental thiamin, especially for protocols requiring high levels of the B vitamin. Its effectiveness, however, has been demonstrated even in low doses (i.e. 150 mg\/d).[1] As compared to thiamin hydrochloride administration, maximum plasma levels are approximately five times higher and bioavailability is, at maximum, approximately 3.6 times as high. These plasma levels are also better than lipophilic thiamin derivatives.[2]\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003ePathways of Glucose-Metabolite–Induced Damage\u003c\/strong\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003eHigh intracellular sugars can lead to an accumulation of intermediate metabolic products. These metabolic products activate certain pathways.[3,4] These pathways are: (1) polyol pathway flux; (2) increased formation of AGEs (advanced glycation end-products); (3) increased expression of the receptor for AGEs (RAGEs) and its activating ligands; (4) activation of protein kinase C (PKC) isoforms; and (5) overactivity of the hexosamine pathway.[4] Together, these mechanisms can impact vascular tissue and target particularly susceptible capillary endothelial cells of the retina, mesangial cells in the renal glomerulus, neuronal cells, and Schwann cells.*[3-7]\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eHighly Absorbed Thiamine Supports Diversion to Different Pathway\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHighly Absorbed Thiamine\u003c\/span\u003e \u003c\/strong\u003ehas been shown to enhance the activity of transketolase, an enzyme that catalyzes the conversion of harmful glucoseintermediate metabolites in the pentose phosphate pathway.[4-7] In vitro research showed treatment with\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eHighly Absorbed Thiamine \u003c\/strong\u003e\u003c\/span\u003ehad an impressive effect on transketolase activity (454% increase from control).[5] Researchers further indicated that increasing transketolase activity supports the diversion of intermediate metabolites away from three of the major pathways (including AGE formation) discussed above. [5]\u003cspan data-mce-fragment=\"1\"\u003e \u003cstrong data-mce-fragment=\"1\"\u003eHighly Absorbed Thiamine\u003c\/strong\u003e\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003ewas shown to have a positive influence on AGE formation and PKC activity. It is thought to prevent NF-kappaB activation in the rat retina as well as inhibit change in the number of retinal acellular capillary segments.*[5] This research has been supported by a human pilot study wherein subjects given\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eHighly Absorbed Thiamine\u003c\/strong\u003e\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e(600 mg\/d) plus alpha-lipoic acid (1200 mg\/d) demonstrated healthy changes in AGE formation, monocyte hexosamine-modified proteins, and prostacyclin synthase activity.*[8]\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eNerve Tissue Health\u003c\/strong\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003eMicrovasculature feeding peripheral nerves can be affected by the pathways discussed herein. Furthermore, lower AGE formation is associated with healthier nerve tissue. The role of\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eHighly Absorbed Thiamine\u003c\/strong\u003e\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003ein diverting glucose metabolites to a less harmful metabolic pathway may well be the underlying reason it has been used successfully in Germany for over a decade to support nerve health. Results suggest that\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003eHighly Absorbed Thiamine\u003c\/strong\u003e\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003eis most effective in large doses (320-600 mg\/d), although effectiveness is still achieved in smaller daily dosages (150 mg\/d).*[1,9,10]\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003cem data-mce-fragment=\"1\"\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.\u003c\/em\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"Vibrant Xience","offers":[{"title":"Default Title","offer_id":41185000882272,"sku":"345","price":39.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8330\/0960\/files\/prod1_5967e492-266c-426a-88b2-8bdc6162e95b.png?v=1724108977","url":"https:\/\/vibrantxience.myshopify.com\/products\/highly-absorbed-thiamine","provider":"Vibrant Xience","version":"1.0","type":"link"}